Drug interactions
Dolutegravir + Eslicarbazepine
Severity: Major
Dolutegravir and Eslicarbazepine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine induces UGT1A1 and CYP3A4 and may lower dolutegravir exposure, risking virologic failure and resistance. Reduced concentrations are expected based on interactions with similar anticonvulsants.
What this interaction means in plain words
Dolutegravir and Eslicarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dolutegravir belongs to Anti Virals; Eslicarbazepine belongs to Central Nervous System.
Why it happens
Induction of UGT1A1 and CYP3A4 by eslicarbazepine accelerates dolutegravir metabolism.
What to do
Avoid the combination if possible or increase dolutegravir to 50 mg twice daily in INSTI-naive patients, and monitor HIV viral load.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dolutegravir
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Dolutegravir with Eslicarbazepine?
MediHelp rates the interaction as major. Dolutegravir and Eslicarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eslicarbazepine induces UGT1A1 and CYP3A4 and may lower dolutegravir exposure, risking virologic failure and resistance. Reduced concentrations are expected based on interactions with similar anticonvulsants.
How serious is the interaction between Dolutegravir and Eslicarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible or increase dolutegravir to 50 mg twice daily in INSTI-naive patients, and monitor HIV viral load.
What other medicines interact with Dolutegravir?
MediHelp also lists interactions of Dolutegravir with, for example, Dofetilide, Aluminum hydroxide, Atidarsagene autotemcel. The full list is on the Dolutegravir page.
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