Drug interactions
Cabotegravir + Nevirapine
Severity: Major
Cabotegravir and Nevirapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral or injectable cabotegravir is used with rilpivirine as a complete regimen and is not intended to be combined with other antiretrovirals. Nevirapine also induces UGT1A1 and CYP3A4, which could lower cabotegravir concentrations and risk virologic failure.
What this interaction means in plain words
Cabotegravir and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabotegravir belongs to Anti Virals; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces UGT1A1 and CYP3A4, lowering cabotegravir exposure.
What to do
Do not combine; use another regimen without nevirapine. Review the full antiretroviral regimen with an HIV specialist.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Cabotegravir
- Apalutamide + Cabotegravir Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Cabotegravir + Oxcarbazepine Contraindicated
- Cabotegravir + Phenobarbitone Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Cabotegravir + Rifabutin Contraindicated
Frequently asked questions
Can I take Cabotegravir with Nevirapine?
MediHelp rates the interaction as major. Cabotegravir and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral or injectable cabotegravir is used with rilpivirine as a complete regimen and is not intended to be combined with other antiretrovirals. Nevirapine also induces UGT1A1 and CYP3A4, which could lower cabotegravir concentrations and risk virologic failure.
How serious is the interaction between Cabotegravir and Nevirapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use another regimen without nevirapine. Review the full antiretroviral regimen with an HIV specialist.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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