Drug interactions
Caffeine + Clomipramine
Severity: Minor
Caffeine and Clomipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caffeine is a CYP1A2 substrate and inhibitor, and clomipramine is partly demethylated via CYP1A2, so high caffeine intake could modestly alter tricyclic levels. Caffeine's stimulant effects may also offset sedation or aggravate anxiety and palpitations.
What this interaction means in plain words
Caffeine and Clomipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Caffeine belongs to Miscellaneous; Clomipramine belongs to Central Nervous System.
Why it happens
Possible competition for CYP1A2 metabolism and opposing CNS effects; the clinical effect is not well established.
What to do
No routine action is needed; advise moderating heavy caffeine intake if anxiety, tremor or palpitations occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Clomipramine?
MediHelp rates the interaction as minor. Caffeine and Clomipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Caffeine is a CYP1A2 substrate and inhibitor, and clomipramine is partly demethylated via CYP1A2, so high caffeine intake could modestly alter tricyclic levels. Caffeine's stimulant effects may also offset sedation or aggravate anxiety and palpitations.
How serious is the interaction between Caffeine and Clomipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; advise moderating heavy caffeine intake if anxiety, tremor or palpitations occur.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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