Drug interactions
Caffeine + Clorazepate
Severity: Minor
Caffeine and Clorazepate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caffeine is a stimulant that can partly counteract the sedative and psychomotor effects of clorazepate, and it may also blunt its anxiolytic effect. The antagonism is incomplete and does not remove the risk of impairment.
What this interaction means in plain words
Caffeine and Clorazepate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Caffeine belongs to Miscellaneous; Clorazepate belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism, as caffeine blocks adenosine receptors while the benzodiazepine enhances GABAergic inhibition.
What to do
No dose change is usually needed. Be aware that high caffeine intake may reduce anxiolytic benefit and that it should not be used to offset sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Clorazepate?
MediHelp rates the interaction as minor. Caffeine and Clorazepate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Caffeine is a stimulant that can partly counteract the sedative and psychomotor effects of clorazepate, and it may also blunt its anxiolytic effect. The antagonism is incomplete and does not remove the risk of impairment.
How serious is the interaction between Caffeine and Clorazepate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Be aware that high caffeine intake may reduce anxiolytic benefit and that it should not be used to offset sedation.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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