Drug interactions
Caffeine + Fluconazole
Severity: Minor
Caffeine and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can reduce caffeine clearance and raise its levels. Effects such as jitteriness, insomnia or palpitations may become more noticeable with high caffeine intake.
What this interaction means in plain words
Caffeine and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Caffeine belongs to Miscellaneous; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP1A2-mediated caffeine metabolism.
What to do
Advise limiting caffeine intake if symptoms of stimulation occur. No dose adjustment of fluconazole is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Fluconazole?
MediHelp rates the interaction as minor. Caffeine and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole can reduce caffeine clearance and raise its levels. Effects such as jitteriness, insomnia or palpitations may become more noticeable with high caffeine intake.
How serious is the interaction between Caffeine and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise limiting caffeine intake if symptoms of stimulation occur. No dose adjustment of fluconazole is needed.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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