Drug interactions
Caffeine + Fluvoxamine
Severity: Moderate
Caffeine and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine strongly inhibits CYP1A2, the main enzyme eliminating caffeine, so caffeine half-life and exposure increase several-fold. Patients may experience jitteriness, insomnia, tachycardia and anxiety from usual caffeine intake.
What this interaction means in plain words
Caffeine and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Caffeine belongs to Miscellaneous; Fluvoxamine belongs to Central Nervous System.
Why it happens
Potent CYP1A2 inhibition by fluvoxamine reduces caffeine clearance.
What to do
Advise patients to reduce coffee, tea, cola and energy drink intake while taking fluvoxamine, and review caffeine-containing medicines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Fluvoxamine?
MediHelp rates the interaction as moderate. Caffeine and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine strongly inhibits CYP1A2, the main enzyme eliminating caffeine, so caffeine half-life and exposure increase several-fold. Patients may experience jitteriness, insomnia, tachycardia and anxiety from usual caffeine intake.
How serious is the interaction between Caffeine and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to reduce coffee, tea, cola and energy drink intake while taking fluvoxamine, and review caffeine-containing medicines.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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