Drug interactions
Caffeine + Itraconazole
Severity: Minor
Caffeine and Itraconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caffeine is metabolised mainly by CYP1A2, and itraconazole has little effect on that enzyme, so any rise in caffeine exposure is expected to be small. Clinically relevant stimulant effects are unlikely at usual intake.
What this interaction means in plain words
Caffeine and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Caffeine belongs to Miscellaneous; Itraconazole belongs to Anti Fungals.
Why it happens
Possible minor reduction in caffeine metabolism; itraconazole is not a significant CYP1A2 inhibitor.
What to do
No dose change is needed; advise patients to report jitteriness, palpitations or insomnia if they consume large amounts of caffeine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Itraconazole?
MediHelp rates the interaction as minor. Caffeine and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Caffeine is metabolised mainly by CYP1A2, and itraconazole has little effect on that enzyme, so any rise in caffeine exposure is expected to be small. Clinically relevant stimulant effects are unlikely at usual intake.
How serious is the interaction between Caffeine and Itraconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; advise patients to report jitteriness, palpitations or insomnia if they consume large amounts of caffeine.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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