Drug interactions
Calaspargase pegol + Ethinyl estradiol-levonorgestrel
Severity: Major
Calaspargase pegol and Ethinyl estradiol-levonorgestrel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asparaginase products can reduce hepatic protein synthesis and alter coagulation, and estrogen-containing contraceptives also raise thrombotic risk and affect hepatic function. Together they may add to the risk of thrombosis and liver toxicity, and the labeling advises against oral contraceptives during treatment.
What this interaction means in plain words
Calaspargase pegol and Ethinyl estradiol-levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Calaspargase pegol belongs to Oncology; Ethinyl estradiol-levonorgestrel belongs to Endocrine.
Why it happens
Indirect pharmacodynamic effects on hepatic protein synthesis and coagulation; the exact mechanism is not firmly established.
What to do
Avoid oral hormonal contraceptives during calaspargase pegol therapy and use a non-oral or non-hormonal method such as an intrauterine device or condoms. Monitor for thrombotic events and liver function if exposure occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Calaspargase pegol
Frequently asked questions
Can I take Calaspargase pegol with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as major. Calaspargase pegol and Ethinyl estradiol-levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Asparaginase products can reduce hepatic protein synthesis and alter coagulation, and estrogen-containing contraceptives also raise thrombotic risk and affect hepatic function. Together they may add to the risk of thrombosis and liver toxicity, and the labeling advises against oral contraceptives during treatment.
How serious is the interaction between Calaspargase pegol and Ethinyl estradiol-levonorgestrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral hormonal contraceptives during calaspargase pegol therapy and use a non-oral or non-hormonal method such as an intrauterine device or condoms. Monitor for thrombotic events and liver function if exposure occurs.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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