Drug interactions
Calaspargase pegol + Ethinyl estradiol-norgestimate
Severity: Moderate
Calaspargase pegol and Ethinyl estradiol-norgestimate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asparaginase products can impair liver function and affect coagulation proteins and thrombosis risk. Estrogen-containing oral contraceptives also alter hepatic protein synthesis and clotting risk, so the combination may add to thrombotic and hepatic risk.
What this interaction means in plain words
Calaspargase pegol and Ethinyl estradiol-norgestimate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calaspargase pegol belongs to Oncology; Ethinyl estradiol-norgestimate belongs to Endocrine.
Why it happens
Not firmly established; likely additive effects on hepatic protein synthesis and coagulation.
What to do
Use a non-oral, non-estrogen contraceptive method during therapy, as the labeling suggests. Monitor liver tests and coagulation parameters.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Calaspargase pegol
Frequently asked questions
Can I take Calaspargase pegol with Ethinyl estradiol-norgestimate?
MediHelp rates the interaction as moderate. Calaspargase pegol and Ethinyl estradiol-norgestimate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asparaginase products can impair liver function and affect coagulation proteins and thrombosis risk. Estrogen-containing oral contraceptives also alter hepatic protein synthesis and clotting risk, so the combination may add to thrombotic and hepatic risk.
How serious is the interaction between Calaspargase pegol and Ethinyl estradiol-norgestimate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-oral, non-estrogen contraceptive method during therapy, as the labeling suggests. Monitor liver tests and coagulation parameters.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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