Drug interactions
Calaspargase pegol + Ethinyl estradiol-drospirenone
Severity: Major
Calaspargase pegol and Ethinyl estradiol-drospirenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asparaginase products can affect hepatic protein synthesis and raise thrombotic and hepatic risks, and estrogen-containing contraceptives also increase thrombosis risk. Labeling advises against oral contraceptives, partly because of this indirect effect.
What this interaction means in plain words
Calaspargase pegol and Ethinyl estradiol-drospirenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Calaspargase pegol belongs to Oncology; Ethinyl estradiol-drospirenone belongs to Endocrine.
Why it happens
Additive prothrombotic and hepatic effects of estrogen and asparaginase; the exact interaction is not firmly established.
What to do
Use a non-oral, non-estrogen contraceptive during therapy. Monitor for thrombosis and liver abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Calaspargase pegol
Frequently asked questions
Can I take Calaspargase pegol with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as major. Calaspargase pegol and Ethinyl estradiol-drospirenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Asparaginase products can affect hepatic protein synthesis and raise thrombotic and hepatic risks, and estrogen-containing contraceptives also increase thrombosis risk. Labeling advises against oral contraceptives, partly because of this indirect effect.
How serious is the interaction between Calaspargase pegol and Ethinyl estradiol-drospirenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-oral, non-estrogen contraceptive during therapy. Monitor for thrombosis and liver abnormalities.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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