Drug interactions
Calaspargase pegol + Drospirenone
Severity: Moderate
Calaspargase pegol and Drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asparaginase products can alter hepatic protein synthesis and affect estrogen-containing oral contraceptives, but drospirenone-only products are less clearly affected. The exact interaction is not well characterised.
What this interaction means in plain words
Calaspargase pegol and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calaspargase pegol belongs to Oncology; Drospirenone belongs to Endocrine.
Why it happens
Not firmly established; hepatic effects of asparaginase may alter hormone-binding protein levels and hormone handling.
What to do
Prefer a non-oral contraceptive method such as an IUD or barrier method during therapy, as labeling advises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Drospirenone
Other interactions of Calaspargase pegol
Frequently asked questions
Can I take Calaspargase pegol with Drospirenone?
MediHelp rates the interaction as moderate. Calaspargase pegol and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asparaginase products can alter hepatic protein synthesis and affect estrogen-containing oral contraceptives, but drospirenone-only products are less clearly affected. The exact interaction is not well characterised.
How serious is the interaction between Calaspargase pegol and Drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-oral contraceptive method such as an IUD or barrier method during therapy, as labeling advises.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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