Drug interactions
Calaspargase pegol + Desogestrel-ethinyl estradiol
Severity: Moderate
Calaspargase pegol and Desogestrel-ethinyl estradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asparaginase products can impair hepatic protein synthesis and raise thrombotic risk, and estrogen-containing contraceptives also increase thrombosis risk. Oral contraceptives may also be unreliable if vomiting or hepatic dysfunction occurs during therapy.
What this interaction means in plain words
Calaspargase pegol and Desogestrel-ethinyl estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calaspargase pegol belongs to Oncology; Desogestrel-ethinyl estradiol belongs to Endocrine.
Why it happens
Additive prothrombotic effects and potential indirect effects on hepatic handling of estrogens; the interaction is not fully characterized.
What to do
Prefer a non-oral, non-estrogen contraceptive method during calaspargase pegol therapy. Monitor for signs of thrombosis if an estrogen product is continued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Calaspargase pegol
Frequently asked questions
Can I take Calaspargase pegol with Desogestrel-ethinyl estradiol?
MediHelp rates the interaction as moderate. Calaspargase pegol and Desogestrel-ethinyl estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asparaginase products can impair hepatic protein synthesis and raise thrombotic risk, and estrogen-containing contraceptives also increase thrombosis risk. Oral contraceptives may also be unreliable if vomiting or hepatic dysfunction occurs during therapy.
How serious is the interaction between Calaspargase pegol and Desogestrel-ethinyl estradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-oral, non-estrogen contraceptive method during calaspargase pegol therapy. Monitor for signs of thrombosis if an estrogen product is continued.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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