Drug interactions
Calaspargase pegol + Levonorgestrel
Severity: Moderate
Calaspargase pegol and Levonorgestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asparaginase products can affect hepatic protein synthesis and may indirectly alter the handling of oral estrogen- or progestin-containing contraceptives. Labeling advises against oral contraceptive use with it.
What this interaction means in plain words
Calaspargase pegol and Levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calaspargase pegol belongs to Oncology; Levonorgestrel belongs to Endocrine.
Why it happens
Mechanism is not firmly established; altered hepatic protein synthesis and binding proteins may indirectly affect hormone disposition.
What to do
Use a non-oral contraceptive method during therapy, such as a barrier method or copper IUD.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levonorgestrel
Other interactions of Calaspargase pegol
Frequently asked questions
Can I take Calaspargase pegol with Levonorgestrel?
MediHelp rates the interaction as moderate. Calaspargase pegol and Levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asparaginase products can affect hepatic protein synthesis and may indirectly alter the handling of oral estrogen- or progestin-containing contraceptives. Labeling advises against oral contraceptive use with it.
How serious is the interaction between Calaspargase pegol and Levonorgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-oral contraceptive method during therapy, such as a barrier method or copper IUD.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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