Drug interactions
Calcifediol + Dexamethasone-tobramycin
Severity: Minor
Calcifediol and Dexamethasone-tobramycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzyme-inducing drugs may accelerate the hydroxylation and clearance of calcifediol, shortening its half-life. Glucocorticoids also oppose vitamin D effects on calcium absorption. Clinical effect with ophthalmic use is small.
What this interaction means in plain words
Calcifediol and Dexamethasone-tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcifediol belongs to Musculoskeletal; Dexamethasone-tobramycin belongs to Anti Bacterial.
Why it happens
Induction of microsomal hydroxylation increases calcifediol catabolism; glucocorticoids also impair intestinal calcium absorption.
What to do
Monitor serum calcium and 25-hydroxyvitamin D or PTH if prolonged systemic dexamethasone is used, and adjust calcifediol dose accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Calcifediol and Dexamethasone-tobramycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dexamethasone-tobramycin
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Calcifediol with Dexamethasone-tobramycin?
MediHelp rates the interaction as minor. Calcifediol and Dexamethasone-tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Enzyme-inducing drugs may accelerate the hydroxylation and clearance of calcifediol, shortening its half-life. Glucocorticoids also oppose vitamin D effects on calcium absorption. Clinical effect with ophthalmic use is small.
How serious is the interaction between Calcifediol and Dexamethasone-tobramycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and 25-hydroxyvitamin D or PTH if prolonged systemic dexamethasone is used, and adjust calcifediol dose accordingly.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
