Drug interactions
Calcifediol + Telmisartan-amlodipine
Severity: Moderate
Calcifediol and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcifediol raises serum calcium by increasing intestinal absorption, and thiazides reduce urinary calcium excretion. If combined, hypercalcemia may develop, particularly with high doses or renal impairment.
What this interaction means in plain words
Calcifediol and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcifediol belongs to Musculoskeletal; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Thiazide-enhanced renal calcium reabsorption adds to vitamin D-driven calcium absorption.
What to do
Monitor serum calcium and adjust the calcifediol dose or review the thiazide if hypercalcemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Calcifediol with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Calcifediol and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcifediol raises serum calcium by increasing intestinal absorption, and thiazides reduce urinary calcium excretion. If combined, hypercalcemia may develop, particularly with high doses or renal impairment.
How serious is the interaction between Calcifediol and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and adjust the calcifediol dose or review the thiazide if hypercalcemia occurs.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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