Drug interactions
Calcitriol + Mitotane
Severity: Moderate
Calcitriol and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong enzyme inducer and can accelerate the breakdown of vitamin D compounds. This may reduce calcitriol effect, and mitotane-related adrenal and bone effects can add to the concern.
What this interaction means in plain words
Calcitriol and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcitriol belongs to Musculoskeletal; Mitotane belongs to Oncology.
Why it happens
Mitotane induces hepatic CYP enzymes, increasing the catabolism of vitamin D metabolites.
What to do
Monitor serum calcium, phosphate and PTH, and increase calcitriol dose if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcitriol
- Amlodipine-hydrochlorothiazide-valsartan + Calcitriol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcitriol Moderate
- Amobarbital + Calcitriol Moderate
- Apalutamide + Calcitriol Moderate
- Atazanavir + Calcitriol Moderate
- Atenolol-chlorthalidone + Calcitriol Moderate
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Calcitriol with Mitotane?
MediHelp rates the interaction as moderate. Calcitriol and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong enzyme inducer and can accelerate the breakdown of vitamin D compounds. This may reduce calcitriol effect, and mitotane-related adrenal and bone effects can add to the concern.
How serious is the interaction between Calcitriol and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, phosphate and PTH, and increase calcitriol dose if the response is inadequate.
What other medicines interact with Calcitriol?
MediHelp also lists interactions of Calcitriol with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Amobarbital. The full list is on the Calcitriol page.
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