Drug interactions
Calcium acetate + Moxifloxacin
Severity: Moderate
Calcium acetate and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium binds moxifloxacin in the gut and can reduce its absorption, potentially lowering antibiotic effectiveness. Calcium acetate is a phosphate binder and is taken with meals, so the overlap can be common.
What this interaction means in plain words
Calcium acetate and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium acetate belongs to Genitourinary; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Chelation of moxifloxacin by calcium (a divalent cation) in the gastrointestinal tract, reducing absorption.
What to do
Give oral moxifloxacin at least 4 hours before or 8 hours after calcium-containing products as per labeling. Time the dose away from meals containing the binder.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Calcium acetate
Frequently asked questions
Can I take Calcium acetate with Moxifloxacin?
MediHelp rates the interaction as moderate. Calcium acetate and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium binds moxifloxacin in the gut and can reduce its absorption, potentially lowering antibiotic effectiveness. Calcium acetate is a phosphate binder and is taken with meals, so the overlap can be common.
How serious is the interaction between Calcium acetate and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral moxifloxacin at least 4 hours before or 8 hours after calcium-containing products as per labeling. Time the dose away from meals containing the binder.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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