Drug interactions
Calcium + Crizotinib
Severity: Minor
Calcium and Crizotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib solubility falls at higher pH, so antacids could theoretically reduce its absorption. No formal studies show a clinically important effect with calcium carbonate.
What this interaction means in plain words
Calcium and Crizotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium belongs to Gastrointestinal Tract; Crizotinib belongs to Oncology.
Why it happens
Elevated gastric pH may reduce crizotinib solubility; effect is theoretical.
What to do
Separate calcium carbonate from crizotinib by about 2 hours and monitor treatment response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Calcium with Crizotinib?
MediHelp rates the interaction as minor. Calcium and Crizotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crizotinib solubility falls at higher pH, so antacids could theoretically reduce its absorption. No formal studies show a clinically important effect with calcium carbonate.
How serious is the interaction between Calcium and Crizotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate calcium carbonate from crizotinib by about 2 hours and monitor treatment response.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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