Drug interactions
Calcium + Dapsone
Severity: Minor
Calcium and Dapsone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Higher gastric pH from calcium carbonate has been proposed to lower dapsone absorption. Clinical significance is uncertain and the effect is probably small.
What this interaction means in plain words
Calcium and Dapsone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium belongs to Gastrointestinal Tract; Dapsone belongs to Anti Bacterial.
Why it happens
Raised gastric pH may reduce dapsone dissolution and absorption, though the effect is poorly documented.
What to do
Separate doses by about 2 hours as a precaution. Monitor clinical response to dapsone if long-term antacid use is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Frequently asked questions
Can I take Calcium with Dapsone?
MediHelp rates the interaction as minor. Calcium and Dapsone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Higher gastric pH from calcium carbonate has been proposed to lower dapsone absorption. Clinical significance is uncertain and the effect is probably small.
How serious is the interaction between Calcium and Dapsone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by about 2 hours as a precaution. Monitor clinical response to dapsone if long-term antacid use is needed.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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