Drug interactions
Calcium + Dasatinib
Severity: Moderate
Calcium and Dasatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium carbonate raises gastric pH, which reduces dissolution and absorption of dasatinib. A short-acting antacid has a smaller effect than acid-suppressing drugs, but exposure may still fall if doses are close together.
What this interaction means in plain words
Calcium and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium belongs to Gastrointestinal Tract; Dasatinib belongs to Oncology.
Why it happens
Dasatinib solubility is pH-dependent, so elevated gastric pH decreases its absorption.
What to do
If an antacid is needed, give it at least 2 hours before or after dasatinib. Avoid H2 blockers and PPIs where possible and monitor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Calcium with Dasatinib?
MediHelp rates the interaction as moderate. Calcium and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium carbonate raises gastric pH, which reduces dissolution and absorption of dasatinib. A short-acting antacid has a smaller effect than acid-suppressing drugs, but exposure may still fall if doses are close together.
How serious is the interaction between Calcium and Dasatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If an antacid is needed, give it at least 2 hours before or after dasatinib. Avoid H2 blockers and PPIs where possible and monitor response.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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