Drug interactions
Calcium + Ethacrynic acid
Severity: Minor
Calcium and Ethacrynic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics increase urinary calcium excretion and may modestly lower serum calcium. This is rarely a problem and can sometimes be used therapeutically in hypercalcemia.
What this interaction means in plain words
Calcium and Ethacrynic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium belongs to Gastrointestinal Tract; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Inhibition of the loop of Henle Na-K-2Cl transporter reduces paracellular calcium reabsorption, increasing calciuria.
What to do
Check serum calcium during prolonged or high-dose diuretic therapy and replace calcium if hypocalcemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Calcium with Ethacrynic acid?
MediHelp rates the interaction as minor. Calcium and Ethacrynic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Loop diuretics increase urinary calcium excretion and may modestly lower serum calcium. This is rarely a problem and can sometimes be used therapeutically in hypercalcemia.
How serious is the interaction between Calcium and Ethacrynic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum calcium during prolonged or high-dose diuretic therapy and replace calcium if hypocalcemia occurs.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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