Drug interactions
Calcium + Furosemide
Severity: Minor
Calcium and Furosemide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide increases urinary calcium excretion and can lower serum calcium. It may therefore reduce the effect of calcium supplements, and it is sometimes used deliberately to treat hypercalcemia. Long-term use may contribute to bone loss and kidney calcification.
What this interaction means in plain words
Calcium and Furosemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium belongs to Gastrointestinal Tract; Furosemide belongs to Cardiovascular.
Why it happens
Loop diuretics inhibit calcium reabsorption in the thick ascending limb, increasing urinary calcium loss.
What to do
Monitor serum calcium during prolonged loop diuretic use, and adjust the calcium dose if hypocalcemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Calcium with Furosemide?
MediHelp rates the interaction as minor. Calcium and Furosemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Furosemide increases urinary calcium excretion and can lower serum calcium. It may therefore reduce the effect of calcium supplements, and it is sometimes used deliberately to treat hypercalcemia. Long-term use may contribute to bone loss and kidney calcification.
How serious is the interaction between Calcium and Furosemide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium during prolonged loop diuretic use, and adjust the calcium dose if hypocalcemia occurs.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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