Drug interactions
Calcium + Moxifloxacin
Severity: Moderate
Calcium and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral calcium may reduce moxifloxacin absorption, although the effect is usually modest. It could contribute to lower antibiotic exposure.
What this interaction means in plain words
Calcium and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium belongs to Gastrointestinal Tract; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Divalent calcium cations chelate the fluoroquinolone in the gastrointestinal tract, reducing absorption.
What to do
Give moxifloxacin at least 4 hours before or 8 hours after calcium supplements, or at least 2 hours separation per local labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Calcium with Moxifloxacin?
MediHelp rates the interaction as moderate. Calcium and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral calcium may reduce moxifloxacin absorption, although the effect is usually modest. It could contribute to lower antibiotic exposure.
How serious is the interaction between Calcium and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give moxifloxacin at least 4 hours before or 8 hours after calcium supplements, or at least 2 hours separation per local labeling.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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