Drug interactions
Calcium + Ursodiol
Severity: Minor
Calcium and Ursodiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aluminium-based antacids are known to bind bile acids and reduce ursodiol absorption, but calcium carbonate is not established to behave in this way. Any effect is likely small and unproven.
What this interaction means in plain words
Calcium and Ursodiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium belongs to Gastrointestinal Tract; Ursodiol belongs to Gastrointestinal Tract.
Why it happens
Possible adsorption of ursodiol in the gut by antacid; not firmly established for calcium salts.
What to do
Separate doses by about 2 hours as a precaution. Monitor liver biochemistry as per routine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Ursodiol
- Aluminum hydroxide + Ursodiol Moderate
- Cholestyramine + Ursodiol Moderate
- Colesevelam + Ursodiol Moderate
- Colestipol + Ursodiol Moderate
- Desogestrel-ethinyl estradiol + Ursodiol Moderate
- Ethinyl estradiol-levonorgestrel + Ursodiol Moderate
Frequently asked questions
Can I take Calcium with Ursodiol?
MediHelp rates the interaction as minor. Calcium and Ursodiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aluminium-based antacids are known to bind bile acids and reduce ursodiol absorption, but calcium carbonate is not established to behave in this way. Any effect is likely small and unproven.
How serious is the interaction between Calcium and Ursodiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by about 2 hours as a precaution. Monitor liver biochemistry as per routine care.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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