Drug interactions
Colesevelam + Ursodiol
Severity: Moderate
Colesevelam and Ursodiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colesevelam can bind ursodiol in the intestine, reducing its absorption and therapeutic effect in cholestatic liver disease or gallstone dissolution.
What this interaction means in plain words
Colesevelam and Ursodiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colesevelam belongs to Endocrine; Ursodiol belongs to Gastrointestinal Tract.
Why it happens
Bile acid sequestrant binds ursodiol in the gut, reducing absorption.
What to do
Separate doses by at least 4 hours, giving ursodiol first, and monitor liver tests or clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Cyclosporine Moderate
Other interactions of Ursodiol
- Aluminum hydroxide + Ursodiol Moderate
- Cholestyramine + Ursodiol Moderate
- Colestipol + Ursodiol Moderate
- Desogestrel-ethinyl estradiol + Ursodiol Moderate
- Ethinyl estradiol-levonorgestrel + Ursodiol Moderate
- Calcium + Ursodiol Minor
Frequently asked questions
Can I take Colesevelam with Ursodiol?
MediHelp rates the interaction as moderate. Colesevelam and Ursodiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colesevelam can bind ursodiol in the intestine, reducing its absorption and therapeutic effect in cholestatic liver disease or gallstone dissolution.
How serious is the interaction between Colesevelam and Ursodiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by at least 4 hours, giving ursodiol first, and monitor liver tests or clinical response.
What other medicines interact with Colesevelam?
MediHelp also lists interactions of Colesevelam with, for example, Amlodipine-olmesartan-hydrochlorothiazide, Amlodipine-olmesartan, Chenodiol. The full list is on the Colesevelam page.
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