Drug interactions
Colestipol + Ursodiol
Severity: Moderate
Colestipol and Ursodiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol binds bile acids in the gut and can bind ursodiol, reducing its absorption and therapeutic effect.
What this interaction means in plain words
Colestipol and Ursodiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colestipol belongs to Cardiovascular; Ursodiol belongs to Gastrointestinal Tract.
Why it happens
Colestipol is an anion-exchange resin that binds ursodiol in the intestinal lumen.
What to do
Avoid concurrent use if possible. If needed, give ursodiol at least 2 hours before or after colestipol and monitor liver tests.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ursodiol
- Aluminum hydroxide + Ursodiol Moderate
- Cholestyramine + Ursodiol Moderate
- Colesevelam + Ursodiol Moderate
- Desogestrel-ethinyl estradiol + Ursodiol Moderate
- Ethinyl estradiol-levonorgestrel + Ursodiol Moderate
- Calcium + Ursodiol Minor
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Colestipol with Ursodiol?
MediHelp rates the interaction as moderate. Colestipol and Ursodiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol binds bile acids in the gut and can bind ursodiol, reducing its absorption and therapeutic effect.
How serious is the interaction between Colestipol and Ursodiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible. If needed, give ursodiol at least 2 hours before or after colestipol and monitor liver tests.
What other medicines interact with Ursodiol?
MediHelp also lists interactions of Ursodiol with, for example, Aluminum hydroxide, Cholestyramine, Colesevelam. The full list is on the Ursodiol page.
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