Drug interactions
Calcium carbonate + Candesartan-hydrochlorothiazide
Severity: Moderate
Calcium carbonate and Candesartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides reduce urinary calcium loss, so large calcium carbonate doses can lead to hypercalcemia and, rarely, milk-alkali syndrome. Risk is higher with renal impairment or concurrent vitamin D.
What this interaction means in plain words
Calcium carbonate and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Candesartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Thiazide-enhanced renal calcium reabsorption combined with calcium load and alkali from carbonate.
What to do
Monitor serum calcium, especially with high-dose calcium or vitamin D. Reduce the calcium dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Candesartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Calcium carbonate and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides reduce urinary calcium loss, so large calcium carbonate doses can lead to hypercalcemia and, rarely, milk-alkali syndrome. Risk is higher with renal impairment or concurrent vitamin D.
How serious is the interaction between Calcium carbonate and Candesartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, especially with high-dose calcium or vitamin D. Reduce the calcium dose if hypercalcemia develops.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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