Drug interactions
Calcium carbonate + Captopril-hydrochlorothiazide
Severity: Moderate
Calcium carbonate and Captopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium carbonate may reduce captopril absorption and lessen its blood pressure effect. Calcium supplements together with thiazides can also raise serum calcium by reducing urinary calcium excretion, with a risk of hypercalcemia.
What this interaction means in plain words
Calcium carbonate and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Captopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Reduced captopril absorption from antacid effect, and reduced renal calcium excretion by thiazides.
What to do
Separate calcium carbonate from captopril by at least 2 hours. Monitor serum calcium in patients on regular high-dose calcium with the thiazide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Calcium carbonate and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium carbonate may reduce captopril absorption and lessen its blood pressure effect. Calcium supplements together with thiazides can also raise serum calcium by reducing urinary calcium excretion, with a risk of hypercalcemia.
How serious is the interaction between Calcium carbonate and Captopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate calcium carbonate from captopril by at least 2 hours. Monitor serum calcium in patients on regular high-dose calcium with the thiazide.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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