Drug interactions
Calcium carbonate + Diflunisal
Severity: Minor
Calcium carbonate and Diflunisal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids raise urinary pH, which increases renal excretion of salicylates. Diflunisal exposure effects are small and inconsistent.
What this interaction means in plain words
Calcium carbonate and Diflunisal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium carbonate belongs to Gastrointestinal Tract; Diflunisal belongs to Musculoskeletal.
Why it happens
Urinary alkalinization alters ionization and renal tubular handling of salicylate-type drugs.
What to do
No routine adjustment is needed. Monitor analgesic response if large antacid doses are taken regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium carbonate
Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Calcium carbonate with Diflunisal?
MediHelp rates the interaction as minor. Calcium carbonate and Diflunisal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antacids raise urinary pH, which increases renal excretion of salicylates. Diflunisal exposure effects are small and inconsistent.
How serious is the interaction between Calcium carbonate and Diflunisal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor analgesic response if large antacid doses are taken regularly.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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