Drug interactions
Calcium carbonate + Enalapril-hydrochlorothiazide
Severity: Minor
Calcium carbonate and Enalapril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium-containing antacids may slightly reduce ACE inhibitor absorption, but the clinical effect is generally small. In addition, thiazides reduce calcium excretion, so large calcium doses may raise serum calcium.
What this interaction means in plain words
Calcium carbonate and Enalapril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium carbonate belongs to Gastrointestinal Tract; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Possible reduced ACE inhibitor absorption, and thiazide-reduced urinary calcium excretion adds to calcium load.
What to do
Separate calcium carbonate and enalapril by about 2 hours. Monitor serum calcium if high-dose calcium is used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Calcium carbonate and Enalapril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium-containing antacids may slightly reduce ACE inhibitor absorption, but the clinical effect is generally small. In addition, thiazides reduce calcium excretion, so large calcium doses may raise serum calcium.
How serious is the interaction between Calcium carbonate and Enalapril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate calcium carbonate and enalapril by about 2 hours. Monitor serum calcium if high-dose calcium is used long term.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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