Drug interactions
Calcium carbonate + Fosinopril-hydrochlorothiazide
Severity: Minor
Calcium carbonate and Fosinopril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium-containing antacids may slightly reduce absorption of fosinopril, which could weaken its effect. Thiazides also reduce urinary calcium excretion, so high calcium intake may raise serum calcium, especially with vitamin D or renal impairment.
What this interaction means in plain words
Calcium carbonate and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium carbonate belongs to Gastrointestinal Tract; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Reduced fosinopril absorption by antacid binding, plus thiazide-reduced renal calcium excretion.
What to do
Separate fosinopril and calcium carbonate by at least 2 hours. Monitor serum calcium if high doses of calcium are used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Calcium carbonate and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium-containing antacids may slightly reduce absorption of fosinopril, which could weaken its effect. Thiazides also reduce urinary calcium excretion, so high calcium intake may raise serum calcium, especially with vitamin D or renal impairment.
How serious is the interaction between Calcium carbonate and Fosinopril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate fosinopril and calcium carbonate by at least 2 hours. Monitor serum calcium if high doses of calcium are used long term.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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