Drug interactions
Calcium carbonate + Hydrochlorothiazide-losartan
Severity: Moderate
Calcium carbonate and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide decreases urinary calcium loss, so calcium supplements can lead to hypercalcemia, and with large carbonate doses, metabolic alkalosis (milk-alkali syndrome). Risk is highest with high doses or renal impairment.
What this interaction means in plain words
Calcium carbonate and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Thiazide-enhanced distal tubular calcium reabsorption adds to calcium intake and alkali load.
What to do
Check serum calcium periodically and avoid high-dose calcium supplements; reduce the dose if calcium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Calcium carbonate and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide decreases urinary calcium loss, so calcium supplements can lead to hypercalcemia, and with large carbonate doses, metabolic alkalosis (milk-alkali syndrome). Risk is highest with high doses or renal impairment.
How serious is the interaction between Calcium carbonate and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum calcium periodically and avoid high-dose calcium supplements; reduce the dose if calcium rises.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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