Drug interactions
Calcium carbonate + Memantine-donepezil
Severity: Minor
Calcium carbonate and Memantine-donepezil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium carbonate can raise urinary pH, which may reduce renal elimination of memantine. Resulting higher levels could increase dizziness, confusion or agitation.
What this interaction means in plain words
Calcium carbonate and Memantine-donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium carbonate belongs to Gastrointestinal Tract; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Urinary alkalinization increases memantine tubular reabsorption and lowers renal clearance.
What to do
Monitor for CNS adverse effects with regular antacid use and reduce the memantine dose if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Memantine-donepezil?
MediHelp rates the interaction as minor. Calcium carbonate and Memantine-donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium carbonate can raise urinary pH, which may reduce renal elimination of memantine. Resulting higher levels could increase dizziness, confusion or agitation.
How serious is the interaction between Calcium carbonate and Memantine-donepezil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for CNS adverse effects with regular antacid use and reduce the memantine dose if they appear.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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