Drug interactions
Calcium carbonate + Neratinib
Severity: Moderate
Calcium carbonate and Neratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Neratinib solubility is pH-dependent, so raising gastric pH with antacids can lower its absorption. Reduced exposure may compromise anticancer efficacy.
What this interaction means in plain words
Calcium carbonate and Neratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Neratinib belongs to Oncology.
Why it happens
Antacid-induced increase in gastric pH decreases neratinib dissolution and absorption.
What to do
Take neratinib at least 3 hours after calcium carbonate. Avoid regular concurrent antacid dosing where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Neratinib
- Amiodarone + Neratinib Major
- Amobarbital + Neratinib Major
- Aprepitant + Neratinib Major
- Armodafinil + Neratinib Major
- Bosentan + Neratinib Major
- Carbamazepine + Neratinib Major
Frequently asked questions
Can I take Calcium carbonate with Neratinib?
MediHelp rates the interaction as moderate. Calcium carbonate and Neratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Neratinib solubility is pH-dependent, so raising gastric pH with antacids can lower its absorption. Reduced exposure may compromise anticancer efficacy.
How serious is the interaction between Calcium carbonate and Neratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take neratinib at least 3 hours after calcium carbonate. Avoid regular concurrent antacid dosing where possible.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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