Drug interactions
Calcium carbonate + Pexidartinib
Severity: Moderate
Calcium carbonate and Pexidartinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Locally acting antacids such as calcium carbonate can reduce pexidartinib absorption. This may lower its effectiveness in tenosynovial giant cell tumor.
What this interaction means in plain words
Calcium carbonate and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Pexidartinib belongs to Oncology.
Why it happens
Antacid-related increase in gastric pH reduces pexidartinib solubility and absorption.
What to do
Take pexidartinib at least 2 hours before or after calcium carbonate. Prefer to avoid acid-reducing agents that act systemically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Pexidartinib
Frequently asked questions
Can I take Calcium carbonate with Pexidartinib?
MediHelp rates the interaction as moderate. Calcium carbonate and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Locally acting antacids such as calcium carbonate can reduce pexidartinib absorption. This may lower its effectiveness in tenosynovial giant cell tumor.
How serious is the interaction between Calcium carbonate and Pexidartinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take pexidartinib at least 2 hours before or after calcium carbonate. Prefer to avoid acid-reducing agents that act systemically.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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