Drug interactions
Calcium carbonate + Riociguat
Severity: Moderate
Calcium carbonate and Riociguat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids reduce the absorption of riociguat, which may lower its exposure and its effect on pulmonary hypertension. Labeling advises separating the two.
What this interaction means in plain words
Calcium carbonate and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Riociguat belongs to Cardiovascular.
Why it happens
Antacids reduce riociguat absorption, likely through raised gastric pH reducing its solubility.
What to do
Give riociguat at least 1 hour before the antacid, and monitor clinical response and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Calcium carbonate with Riociguat?
MediHelp rates the interaction as moderate. Calcium carbonate and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids reduce the absorption of riociguat, which may lower its exposure and its effect on pulmonary hypertension. Labeling advises separating the two.
How serious is the interaction between Calcium carbonate and Riociguat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give riociguat at least 1 hour before the antacid, and monitor clinical response and blood pressure.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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