Drug interactions
Calcium carbonate + Sulphasalazine
Severity: Minor
Calcium carbonate and Sulphasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids can alter urinary pH and thereby salicylate excretion, but the effect is relevant mainly with high-dose salicylates. With sulfasalazine the impact is expected to be negligible.
What this interaction means in plain words
Calcium carbonate and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium carbonate belongs to Gastrointestinal Tract; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Theoretical change in renal salicylate reabsorption with urinary pH shifts.
What to do
No routine action required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Asciminib + Sulphasalazine Moderate
Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Sulphasalazine?
MediHelp rates the interaction as minor. Calcium carbonate and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antacids can alter urinary pH and thereby salicylate excretion, but the effect is relevant mainly with high-dose salicylates. With sulfasalazine the impact is expected to be negligible.
How serious is the interaction between Calcium carbonate and Sulphasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action required.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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