Drug interactions
Calcium carbonate + Verapamil
Severity: Moderate
Calcium carbonate and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium can reduce the effects of verapamil, and intravenous calcium has been used to reverse its toxicity. Oral supplements at usual doses seldom cause problems, but hypercalcemia could diminish verapamil's antihypertensive or antiarrhythmic effect.
What this interaction means in plain words
Calcium carbonate and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Verapamil belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism: higher extracellular calcium overcomes calcium channel blockade.
What to do
Monitor blood pressure, heart rate and serum calcium when high-dose calcium or vitamin D is given. Avoid parenteral calcium unless treating verapamil toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Calcium carbonate with Verapamil?
MediHelp rates the interaction as moderate. Calcium carbonate and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium can reduce the effects of verapamil, and intravenous calcium has been used to reverse its toxicity. Oral supplements at usual doses seldom cause problems, but hypercalcemia could diminish verapamil's antihypertensive or antiarrhythmic effect.
How serious is the interaction between Calcium carbonate and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum calcium when high-dose calcium or vitamin D is given. Avoid parenteral calcium unless treating verapamil toxicity.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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