Drug interactions
Calcium citrate + Cholecalciferol
Severity: Moderate
Calcium citrate and Cholecalciferol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vitamin D increases calcium absorption, and combined with calcium citrate it may lead to hypercalcemia in some patients. The combination is commonly used intentionally.
What this interaction means in plain words
Calcium citrate and Cholecalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Vitamin D enhances intestinal calcium absorption, adding to the calcium load.
What to do
Monitor serum calcium, especially with high doses or renal impairment. Reduce the dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cholecalciferol
- Cholecalciferol + Digoxin Major
- Aluminum hydroxide + Cholecalciferol Moderate
- Calcium acetate + Cholecalciferol Moderate
- Calcium Carbonate + Cholecalciferol Moderate
- Calcium chloride + Cholecalciferol Moderate
- Calcium gluconate + Cholecalciferol Moderate
Frequently asked questions
Can I take Calcium citrate with Cholecalciferol?
MediHelp rates the interaction as moderate. Calcium citrate and Cholecalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vitamin D increases calcium absorption, and combined with calcium citrate it may lead to hypercalcemia in some patients. The combination is commonly used intentionally.
How serious is the interaction between Calcium citrate and Cholecalciferol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, especially with high doses or renal impairment. Reduce the dose if hypercalcemia develops.
What other medicines interact with Cholecalciferol?
MediHelp also lists interactions of Cholecalciferol with, for example, Digoxin, Aluminum hydroxide, Calcium acetate. The full list is on the Cholecalciferol page.
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