Drug interactions
Calcium acetate + Cholecalciferol
Severity: Moderate
Calcium acetate and Cholecalciferol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vitamin D increases intestinal calcium absorption, and combined with calcium acetate it may cause hypercalcemia. The risk is higher in renal impairment or with high doses.
What this interaction means in plain words
Calcium acetate and Cholecalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium acetate belongs to Genitourinary; Cholecalciferol belongs to Musculoskeletal.
Why it happens
Additive effect: vitamin D enhances intestinal calcium absorption.
What to do
Monitor serum calcium and phosphate periodically. Reduce the calcium or vitamin D dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cholecalciferol
- Cholecalciferol + Digoxin Major
- Aluminum hydroxide + Cholecalciferol Moderate
- Calcium Carbonate + Cholecalciferol Moderate
- Calcium chloride + Cholecalciferol Moderate
- Calcium citrate + Cholecalciferol Moderate
- Calcium gluconate + Cholecalciferol Moderate
Other interactions of Calcium acetate
Frequently asked questions
Can I take Calcium acetate with Cholecalciferol?
MediHelp rates the interaction as moderate. Calcium acetate and Cholecalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vitamin D increases intestinal calcium absorption, and combined with calcium acetate it may cause hypercalcemia. The risk is higher in renal impairment or with high doses.
How serious is the interaction between Calcium acetate and Cholecalciferol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and phosphate periodically. Reduce the calcium or vitamin D dose if hypercalcemia develops.
What other medicines interact with Cholecalciferol?
MediHelp also lists interactions of Cholecalciferol with, for example, Digoxin, Aluminum hydroxide, Calcium Carbonate. The full list is on the Cholecalciferol page.
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