Drug interactions
Calcium citrate + Ergocalciferol
Severity: Moderate
Calcium citrate and Ergocalciferol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vitamin D increases intestinal calcium absorption, and calcium citrate adds to the calcium load. Together they can cause hypercalcemia, particularly in patients with renal impairment or at high doses.
What this interaction means in plain words
Calcium citrate and Ergocalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect: vitamin D enhances calcium absorption and raises serum calcium.
What to do
Monitor serum calcium periodically and lower the dose of either agent if hypercalcemia or hypercalciuria occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Calcium citrate and Ergocalciferol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ergocalciferol
- Aluminum hydroxide + Ergocalciferol Moderate
- Calcium acetate + Ergocalciferol Moderate
- Calcium carbonate + Ergocalciferol Moderate
- Calcium chloride + Ergocalciferol Moderate
- Calcium gluconate + Ergocalciferol Moderate
- Chlorothiazide + Ergocalciferol Moderate
Frequently asked questions
Can I take Calcium citrate with Ergocalciferol?
MediHelp rates the interaction as moderate. Calcium citrate and Ergocalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vitamin D increases intestinal calcium absorption, and calcium citrate adds to the calcium load. Together they can cause hypercalcemia, particularly in patients with renal impairment or at high doses.
How serious is the interaction between Calcium citrate and Ergocalciferol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically and lower the dose of either agent if hypercalcemia or hypercalciuria occurs.
What other medicines interact with Ergocalciferol?
MediHelp also lists interactions of Ergocalciferol with, for example, Aluminum hydroxide, Calcium acetate, Calcium carbonate. The full list is on the Ergocalciferol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
