Drug interactions
Calcium gluconate + Hydrochlorothiazide-losartan
Severity: Moderate
Calcium gluconate and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides reduce urinary calcium excretion, so calcium given orally or intravenously can lead to hypercalcemia, especially with high doses or reduced kidney function.
What this interaction means in plain words
Calcium gluconate and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium gluconate belongs to Gastrointestinal Tract; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Thiazide-induced increase in renal tubular calcium reabsorption adds to calcium intake.
What to do
Monitor serum calcium when calcium is given repeatedly or at high doses. Reduce the calcium dose if hypercalcemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Calcium gluconate
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium gluconate + Digoxin Major
- Alendronate + Calcium gluconate Moderate
- Amlodipine-atorvastatin + Calcium gluconate Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Calcium gluconate Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcium gluconate Moderate
Frequently asked questions
Can I take Calcium gluconate with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Calcium gluconate and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides reduce urinary calcium excretion, so calcium given orally or intravenously can lead to hypercalcemia, especially with high doses or reduced kidney function.
How serious is the interaction between Calcium gluconate and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium when calcium is given repeatedly or at high doses. Reduce the calcium dose if hypercalcemia occurs.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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