Drug interactions
Calcium gluconate + Levofloxacin
Severity: Moderate
Calcium gluconate and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral calcium gluconate may bind levofloxacin in the intestine and decrease its absorption, risking reduced antibacterial effect. Intravenous calcium gluconate is not expected to interact this way.
What this interaction means in plain words
Calcium gluconate and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium gluconate belongs to Gastrointestinal Tract; Levofloxacin belongs to Anti Bacterial.
Why it happens
Chelation of levofloxacin by calcium cations in the gastrointestinal lumen.
What to do
Separate oral levofloxacin and oral calcium gluconate by at least 2 hours, giving levofloxacin first.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Calcium gluconate
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium gluconate + Digoxin Major
- Alendronate + Calcium gluconate Moderate
- Amlodipine-atorvastatin + Calcium gluconate Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Calcium gluconate Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcium gluconate Moderate
Frequently asked questions
Can I take Calcium gluconate with Levofloxacin?
MediHelp rates the interaction as moderate. Calcium gluconate and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral calcium gluconate may bind levofloxacin in the intestine and decrease its absorption, risking reduced antibacterial effect. Intravenous calcium gluconate is not expected to interact this way.
How serious is the interaction between Calcium gluconate and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral levofloxacin and oral calcium gluconate by at least 2 hours, giving levofloxacin first.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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