Drug interactions
Calcium gluconate + Nicardipine
Severity: Moderate
Calcium gluconate and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous calcium gluconate can reduce the hypotensive and cardiac effects of calcium channel blockers. It is used to treat their toxicity, so unplanned administration may reduce nicardipine efficacy.
What this interaction means in plain words
Calcium gluconate and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium gluconate belongs to Gastrointestinal Tract; Nicardipine belongs to Cardiovascular.
Why it happens
Increased extracellular calcium antagonises L-type calcium channel blockade.
What to do
Give IV calcium only when indicated and monitor blood pressure and ECG. Expect reduced nicardipine effect and adjust the infusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Calcium gluconate
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium gluconate + Digoxin Major
- Alendronate + Calcium gluconate Moderate
- Amlodipine-atorvastatin + Calcium gluconate Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Calcium gluconate Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcium gluconate Moderate
Frequently asked questions
Can I take Calcium gluconate with Nicardipine?
MediHelp rates the interaction as moderate. Calcium gluconate and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous calcium gluconate can reduce the hypotensive and cardiac effects of calcium channel blockers. It is used to treat their toxicity, so unplanned administration may reduce nicardipine efficacy.
How serious is the interaction between Calcium gluconate and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give IV calcium only when indicated and monitor blood pressure and ECG. Expect reduced nicardipine effect and adjust the infusion.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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