Drug interactions
Calcium / magnesium / potassium / sodium oxybates + Metoclopramide
Severity: Major
Calcium / magnesium / potassium / sodium oxybates and Metoclopramide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybates cause profound CNS and respiratory depression, and metoclopramide adds further sedation. The combination can increase the risk of excessive drowsiness, impaired consciousness and respiratory compromise.
What this interaction means in plain words
Calcium / magnesium / potassium / sodium oxybates and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depressant effects.
What to do
Avoid the combination when an alternative antiemetic is available. If used, give the lowest effective metoclopramide dose and monitor sedation and respiratory status closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Calcium / magnesium / potassium / sodium oxybates with Metoclopramide?
MediHelp rates the interaction as major. Calcium / magnesium / potassium / sodium oxybates and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxybates cause profound CNS and respiratory depression, and metoclopramide adds further sedation. The combination can increase the risk of excessive drowsiness, impaired consciousness and respiratory compromise.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Metoclopramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when an alternative antiemetic is available. If used, give the lowest effective metoclopramide dose and monitor sedation and respiratory status closely.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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