Drug interactions
Calcium / magnesium / potassium / sodium oxybates + Prochlorperazine
Severity: Major
Calcium / magnesium / potassium / sodium oxybates and Prochlorperazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybates are potent CNS depressants, and coadministration with a sedating phenothiazine may cause profound sedation, respiratory depression, coma and death. Oxybate labeling warns about use with other CNS depressants.
What this interaction means in plain words
Calcium / magnesium / potassium / sodium oxybates and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression.
What to do
Avoid if possible; otherwise reduce the oxybate dose or choose a non-sedating antiemetic, and monitor closely for respiratory depression and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Calcium / magnesium / potassium / sodium oxybates and Prochlorperazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Calcium / magnesium / potassium / sodium oxybates with Prochlorperazine?
MediHelp rates the interaction as major. Calcium / magnesium / potassium / sodium oxybates and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxybates are potent CNS depressants, and coadministration with a sedating phenothiazine may cause profound sedation, respiratory depression, coma and death. Oxybate labeling warns about use with other CNS depressants.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Prochlorperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the oxybate dose or choose a non-sedating antiemetic, and monitor closely for respiratory depression and sedation.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
