Drug interactions
Canagliflozin + Candesartan
Severity: Moderate
Canagliflozin and Candesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin may cause volume depletion and renal function changes, and labeling notes possible increases in potassium. With candesartan the risk of hypotension, acute kidney injury and hyperkalemia can be increased, especially in older or renally impaired patients.
What this interaction means in plain words
Canagliflozin and Candesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Candesartan belongs to Cardiovascular.
Why it happens
Additive effects on renal hemodynamics: SGLT2-induced volume contraction with ARB-mediated efferent arteriolar dilation and reduced aldosterone effect.
What to do
Assess volume status before starting canagliflozin and monitor renal function, potassium and blood pressure afterwards. Consider reducing diuretic doses if volume depleted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Candesartan?
MediHelp rates the interaction as moderate. Canagliflozin and Candesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin may cause volume depletion and renal function changes, and labeling notes possible increases in potassium. With candesartan the risk of hypotension, acute kidney injury and hyperkalemia can be increased, especially in older or renally impaired patients.
How serious is the interaction between Canagliflozin and Candesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status before starting canagliflozin and monitor renal function, potassium and blood pressure afterwards. Consider reducing diuretic doses if volume depleted.
What other medicines interact with Candesartan?
MediHelp also lists interactions of Candesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Candesartan page.
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