Drug interactions
Canagliflozin + Chlorpropamide
Severity: Moderate
Canagliflozin and Chlorpropamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin added to chlorpropamide increases hypoglycemia risk. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged, especially in older patients or those with renal impairment.
What this interaction means in plain words
Canagliflozin and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Chlorpropamide belongs to Endocrine.
Why it happens
Additive glucose lowering from sulfonylurea-stimulated insulin secretion and SGLT2-mediated glucosuria.
What to do
Consider reducing the chlorpropamide dose when starting canagliflozin and monitor blood glucose closely, particularly in older or renally impaired patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Chlorpropamide?
MediHelp rates the interaction as moderate. Canagliflozin and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin added to chlorpropamide increases hypoglycemia risk. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged, especially in older patients or those with renal impairment.
How serious is the interaction between Canagliflozin and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the chlorpropamide dose when starting canagliflozin and monitor blood glucose closely, particularly in older or renally impaired patients.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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