Drug interactions
Canagliflozin + Cyclosporin
Severity: Moderate
Canagliflozin and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can cause hyperkalemia and renal impairment, and canagliflozin may affect potassium and renal hemodynamics. Using them together may modestly raise the risk of elevated potassium and changes in kidney function.
What this interaction means in plain words
Canagliflozin and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Cyclosporin belongs to Miscellaneous.
Why it happens
Additive effects on potassium homeostasis and renal hemodynamics; the combined effect is mostly theoretical.
What to do
Monitor serum potassium, creatinine and volume status when starting canagliflozin in patients on cyclosporine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Cyclosporin?
MediHelp rates the interaction as moderate. Canagliflozin and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine can cause hyperkalemia and renal impairment, and canagliflozin may affect potassium and renal hemodynamics. Using them together may modestly raise the risk of elevated potassium and changes in kidney function.
How serious is the interaction between Canagliflozin and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, creatinine and volume status when starting canagliflozin in patients on cyclosporine.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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