Drug interactions
Canagliflozin + Drospirenone
Severity: Minor
Canagliflozin and Drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium. Canagliflozin is not typically hyperkalemic, though it may cause volume depletion and renal effects that could add to risk in susceptible patients.
What this interaction means in plain words
Canagliflozin and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canagliflozin belongs to Endocrine; Drospirenone belongs to Endocrine.
Why it happens
Drospirenone antagonizes aldosterone; canagliflozin contributes only indirectly via volume and renal effects.
What to do
Check potassium in patients with renal impairment or other hyperkalemia risk factors; routine monitoring is otherwise sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Canagliflozin and Drospirenone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Canagliflozin
Other interactions of Drospirenone
Frequently asked questions
Can I take Canagliflozin with Drospirenone?
MediHelp rates the interaction as minor. Canagliflozin and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone has antimineralocorticoid activity and can raise serum potassium. Canagliflozin is not typically hyperkalemic, though it may cause volume depletion and renal effects that could add to risk in susceptible patients.
How serious is the interaction between Canagliflozin and Drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium in patients with renal impairment or other hyperkalemia risk factors; routine monitoring is otherwise sufficient.
What other medicines interact with Canagliflozin?
MediHelp also lists interactions of Canagliflozin with, for example, Aliskiren, Amiloride, Amlodipine-benazepril. The full list is on the Canagliflozin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
